Pilonidal sinus is a common condition characterized by the development of a small tunnel or cavity in the skin near the tailbone. While traditional treatments such as surgical excision have been the mainstay of management, ongoing research and innovation in the field have led to the development of emerging therapies aimed at improving outcomes and reducing the recurrence rate of pilonidal sinus. In this article, we will explore the latest advancements in pilonidal sinus management, including minimally invasive procedures, novel surgical techniques, and promising experimental therapies.

Laser Therapy

Laser therapy is a non-invasive treatment modality that shows promise in the management of pilonidal sinus. High-intensity laser energy is directed at the sinus tract, causing selective destruction of diseased tissue while sparing surrounding healthy tissue. Laser therapy offers several potential advantages, including minimal discomfort, shorter recovery times, and reduced risk of complications compared to traditional surgical techniques. Preliminary studies have shown promising results with laser therapy in terms of symptom relief and wound healing, although further research is needed to establish its long-term efficacy and safety.

Endoscopic Pilonidal Sinus Treatment (EPSiT)

Endoscopic pilonidal sinus treatment (EPSiT) is a minimally invasive procedure that involves the use of an endoscope to visualize and treat pilonidal sinus tracts. During EPSiT, small incisions are made near the sinus openings, and an endoscope equipped with a camera and specialized instruments is inserted to identify and remove diseased tissue. EPSiT offers several potential benefits, including reduced postoperative pain, faster recovery, and lower rates of recurrence compared to conventional surgical techniques. While EPSiT shows promise as a less invasive alternative for select patients with pilonidal sinus, further research is needed to determine its long-term outcomes and effectiveness.

Biological Therapies

Biological therapies, such as platelet-rich plasma (PRP) and stem cell therapy, are emerging as potential treatment options for pilonidal sinus. PRP is a concentrated solution of platelets obtained from the patient’s own blood, which contains growth factors and cytokines that promote tissue repair and regeneration. Stem cell therapy involves the injection of mesenchymal stem cells derived from adipose tissue or bone marrow into the sinus tract, with the aim of stimulating tissue healing and reducing inflammation. While preliminary studies have shown promising results with biological therapies in terms of wound healing and symptom improvement, larger clinical trials are needed to validate their efficacy and safety in the management of pilonidal sinus.

Injectable Sealants

Injectable sealants, such as fibrin glue and cyanoacrylate-based adhesives, are being investigated as potential adjunctive therapies for pilonidal sinus. These sealants are injected into the sinus tract to fill the cavity and promote wound closure, thereby reducing the risk of recurrence and facilitating healing. Injectable sealants offer several potential advantages, including ease of administration, minimal invasiveness, and shorter recovery times compared to traditional surgical techniques. While early studies have shown promising results with injectable sealants in terms of reducing recurrence rates and improving patient outcomes, further research is needed to determine their long-term efficacy and safety.


Research and innovation in pilonidal sinus management are paving the way for new treatment modalities aimed at improving outcomes and reducing the burden of this common condition. Laser therapy, endoscopic pilonidal sinus treatment (EPSiT), biological therapies, and injectable sealants represent promising emerging therapies that offer potential advantages in terms of effectiveness, safety, and patient satisfaction. While further research is needed to establish the long-term efficacy and safety of these emerging therapies, they hold the potential to revolutionize the management of pilonidal sinus and improve the quality of life for patients affected by this condition.




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